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DNA test to predict obesity levels

Obesity

Obesity

Scientists have developed a simple DNA blood test which they claim can predict obesity levels in children as they grow up.

Researchers at the Universities of Southampton, Exeter and Plymouth have found that the test which is carried out when a child is five years old can predict how much body fat they will have when they are 14.

The test checks a gene called the PGC1 that regulates fat storage in the body.

Dr Graham Burdge, of the University of Southampton said: “It can be difficult to predict when children are very young, which children will put on weight or become obese. It is important to know which children are at risk because help, such as suggestions about their diet, can be offered early and before they start to gain weight.

“The results of our study provide further evidence that being overweight or obese in childhood is not just due to lifestyle, but may also involve important basic processes that control our genes.

“We hope that this knowledge will help us to develop and test new ways to prevent children developing obesity which can be introduced before a child starts to gain excess weight. However, our findings now need to be tested in larger groups of children.”

The study, which also involved Professor Terence Wilkin at the University of Exeter and Dr Joanne Hosking at the University of Plymouth, is published in the journal Diabetes. The researchers used DNA samples from 40 children who took part in the EarlyBird project, which studied 300 children in Plymouth from the age of five until they were 14 years old.

Led by Professor Wilkin, the study assessed the children in Plymouth each year for factors related to type 2 diabetes, such as the amount of exercise they undertook and the amount of fat in their body. A blood sample was collected and stored. The Southampton team extracted DNA from these blood samples to test for epigenetic switches.

Epigenetic switches take place through a chemical change called DNA methylation, which controls how genes work and is set during early life.

The Southampton team found that a rise in DNA methylation levels of 10% at five years was associated with up to 12% more body fat at 14 years. Results were independent of the child’s gender, their amount of physical activity and their timing of puberty.

Prof Wilkin said: “The EarlyBird study has already provided important information about the causes of obesity in children. Now samples stored during the study have provided clues about the role of fundamental processes that affect how genes work, over which a child has no control.

“This has shown that these mechanisms can affect their health during childhood and as adults.”

 

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