Lisa McMurray, who was in her 30s and who was diagnosed with an African strain of the rabies virus last month, had been battling for her life in the Royal Victoria Hospital.

A statement on Tuesday evening, issued in the name of Lisa's brothers, confirmed their sister's death.

Her family referred to their pride in Lisa and the "bravery with which she fought her illness".

"Her courage was inspiring and typical of the passionate and determined way in which she led her life. Her loss will leave a huge hole in all our lives and her family and friends will miss her terribly," the statement read.

"We would like to take this opportunity to thank the medical staff who have treated Lisa throughout her illness. Their skill and dedication has been a great source of comfort to us and they did everything possible to care for her.

"The sensitive way in which they cared not only for Lisa but for her family and friends has been exceptional and we are very grateful.

"Our thanks go to all those whose thoughts and prayers have helped to sustain us over the past weeks," the statement added.

Ms McMurray had been to Africa a number of times over the last couple of years but began to feel unwell after being home for a few months.

It has been reported that Lisa had sent emails in December 2006 detailing how she was scratched separating dogs at an animal sanctuary in South Africa.

She told friends one of the dogs, which was subsequently put down by the sanctuary owner, was foaming at the mouth.

Lisa had worked as communications director for the Belfast Visitor and Convention Bureau (BVCB) in the city centre until last year.

She had recently moved jobs a few months ago to work for the Cats Protection NI Adoption Centre at Dundonald.

Her illness was believed to be the first rabies case in Northern Ireland for 70 years.

The disease, which is prevalent in parts of Africa, Asia and South America, affects the central nervous system.