Rainey and Armagh, both impressive winners on the opening day of the season, meet at Hatrick Park today.
The Old Boys beat Ards 52-22 while Armagh beat Dungannon 20-0.
Rainey are without prop Noel O’Kane and loose forward Paul Heaney.
Richard Hall comes into the front row with former Ballymena Academy prop Adam Kirk providing cover on the bench.
Heaney’s absent sees a reshuffle in the backrow with former Ulster Schools openside Michael Dawson getting a start, Stephen Mulholland moves to blindside and Colin Mitchell switches to No8.
Behind the pack Jack Fleming keeps his place at scrum half after an impressive display at the Palace Grounds and there is plenty of pace on the wings with Nicholas Sterling and Kyle Moore.
Ballynahinch beat Malone in the final game of last season to clinch the Ulster Senior League title and the two renew acquaintances at Gibson Park.
Both enjoyed wins on the opening day with Hinch beating City of Derry and Malone edging out Banbridge.
Queen’s lost a classic at Eaton Park last week going down 46-44 and will be looking to bounce back at the Dub against Ards.
Prop Mark Foster and lock Grant Bartley are both unavailable but flanker Robert Whitten returns to the back row.
Ulster Raven Michael McAuley returns after a long injury lay off and partners Robbie Stewart in midfield.
Instonians coach Wilbur Leacock makes four changes from the team that lost at Belfast Harlequins last week for the visit of Banbridge to Shaw’s Bridge.
Loose head prop Harry Martin has returned from university and makes his debut while Ross Keane and Josh Cregan keep their places in the front row.
Andrew Mairs comes into the second row with Paddy Marks switching to openside flanker.
Behind the pack Ross O’Donnell continues a long family tradition of playing at scrum half for Instonians. Three generations of the O’Donnell family have donned the No9 shirt over the last 60 years.
Centre Matt McClelland a summer signing from Rainey makes his debut and partners Matt Kilpatrick.
In the other games City of Derry host Ballymena while Dungannon entertain Belfast Harlequins.