A spokesman for the president’s office said they both displayed mild symptoms of Covid-19 and will isolate for the next seven days.
The president will continue to work from Aras an Uachtarain.
Mr Higgins resumed his public appearances last year after the vast majority were cancelled due to the pandemic.
Many people sent well wishes to the president and his wife on social media.
Thousands of people are still testing positive for the virus in Ireland.
The Department of Health were notified of 4,042 PCR-confirmed cases of Covid-19 on Thursday.
Another 4,746 people registered a positive antigen test on the HSE portal.