Al Kellock returns to the Glasgow side for Saturday’s PRO12 match with Ulster at a sold-out Scotstoun Stadium.
The Warriors captain, who replaces the injured Tim Swinson in the second-row, could be making his final appearance at Scotstoun, following the announcement that he is to retire from rugby at the end of the season.
Following last week’s defeat to the Ospreys, Sean Lamont returns from injury and replaces Niko Matawalu on the left wing, with the Fijian international moving to scrum-half in place of Henry Pyrgos.
The only other change to the backline sees Finn Russell come in for Duncan Weir at stand-off.
Glasgow head coach Gregor Townsend said: “We had heard that there might be some sort of rotation (in Ulster).
“We talked this morning about whether they would start with their perceived strongest team or - as it looks like they have done - mix things up a bit with some of their usual starters on the bench.
“We expect them to come on at some stage of the game.
“Ulster have always had a strong squad so no matter who they pick they are going to be competitive.
“Last year, they picked a second team against Munster and beat them away at Thomond Park - so we know we will be playing against a highly motivated team with a really strong bench.”
Glasgow Warriors: S Hogg; T Seymour, R Vernon, P Horne, S Lamont; F Russell, N Matawalu; R Grant, D Hall, R de Klerk; J Gray, Al Kellock (c); J Strauss, C Fusaro, A Ashe
Replacements: P MacArthur, G Reid, M Cusack, L Nakarawa, R Wilson, H Pyrgos, D Weir, P Murchie.