Belfast Harlequins and Malone are still embroiled in the Division 1A relegation battle.
Quins are two points above the drop zone in seventh with their cross city rivals a point and a place further back.
Adam Larkin’s side could take a huge step towards survival as they host Shannon at Deramore; the Limerick side are three points and a place above Quins.
Quins nearly toppled second placed Garryowen last time out but had to settle for a losing bonus point.
Ulster flanker Sean Reidy is available, while in the back division Mark Kettyle returns at No10 while Mark Glover switches to the wing.
Malone travel to bottom of the table UL Bohemians in what is the proverbial eight-pointer, with Jacque Benade’s side only having won one of their last seven games in all competitions.
In Division 2B Ards have five games to save their senior status and are seven points adrift at the bottom of the table and travel to Old Crescent while Armagh travel to Boyne.