Top neurologist shares ways to stall development of Alzheimer’s disease
Discovering his Alzheimer’s early gave Dr Daniel Gibbs an opportunity to try and halt its progress
While he admits he’s “disappointed” to have the disease, Gibbs says he’s also “fascinated” by it – and considers himself lucky. He stumbled upon his diagnosis 10 years ago, before he developed any cognitive symptoms (Gibbs took a DNA test to trace his ancestry, which revealed genetic links to Alzheimer’s). This ultimately gave him the chance to tackle it very early on.
“It’s easy to say I’m unlucky to have Alzheimer’s,” says Gibbs. “But in truth, I’m lucky to have found what I found, when I found it.”
As a result, the American neurologist, now 69, has devoted his life to researching the disease and what can be done to slow its progress. He’s now explained his findings in a new book – A Tattoo On My Brain: A Neurologist’s Personal Battle Against Alzheimer’s Disease – which reveals the lifestyle choices Gibbs, and many in the dementia community, believe can help slow the progress of Alzheimer’s, particularly in its early stages. And by early, he means before there are even any symptoms (there can be changes in a brain with Alzheimer’s up to 20 years before there are any cognitive signs, Gibbs points out).
He says he’s “still doing well” but Gibbs started getting cognitive symptoms around nine years ago, when he began having problems remembering the names of colleagues, and retired soon after. He now has increasing problems with his short-term memory, often can’t recall what he did an hour ago, and needs to write down all his plans and keep a meticulous calendar. Still, he insists: “Most people would have no idea I have Alzheimer’s.”
Gibbs believes the lifestyle modifications he’s made since his diagnosis have helped slow the progression of the disease, and says such lifestyle measures also appear to reduce the risk of getting Alzheimer’s in the first place. “The important message is all of these modifications are likely to be most effective when started early, before there’s been any cognitive impairment,” he says.
“The pathological changes in the brain that result in Alzheimer’s disease begin years before the onset of cognitive impairment – up to 20 years for the amyloid plaques. Once nerve cells in the brain start to die off and cognitive impairment begins, lifestyle modifications seem to have less, if any, impact.”
Gibbs says the same is probably true for drugs, adding: “The time to intervene, both with lifestyle modifications and with potential drugs, is almost certainly early, before significant cognitive impairment has occurred.”
Gibbs is one of 50 million people worldwide with an Alzheimer’s disease diagnosis.
Forewarned by genetic testing showing he carried alleles that increased the risk of developing the disease, he noticed symptoms of mild cognitive impairment long before any tests would have alerted him.
Now years on from his diagnosis — Gibbs, who retired from practice at the Oregon Health & Science University in Portland, wants to clear the air about Alzheimer’s disease. By avoiding discussions about the “A” word, he says, high-risk individuals could miss out on potential opportunities to delay a diagnosis or slow the progression of the disease.
In his highly personal account, Dr Gibbs documents the effect his diagnosis has had on his life and explains his advocacy for improving early recognition.
Weaving clinical knowledge from decades caring for dementia patients with his personal experience of the disease, this is an optimistic tale of one man’s journey with early-stage Alzheimer’s disease.
Although the Alzheimer’s Society (alzheimers.org.uk) hasn’t seen Gibbs’ book, Dr Tim Beanland, the society’s head of knowledge, agrees healthy lifestyle measures are thought to help slow the disease’s progress. “There’s growing evidence to suggest regular exercise, looking after your health, and keeping mentally and socially active can help reduce the progression of dementia symptoms,” says Beanland.
“We know that what’s good for the heart is good for the brain, so a healthy diet and lifestyle, including not smoking or drinking too much alcohol, can help lower your risk of dementia, and other conditions like heart disease, stroke, diabetes and some cancers.”
Here, Gibbs outlines steps people can take to help reduce the risk and slow the progress of Alzheimer’s in its very early stages...
According to the Alzheimer’s Research and Prevention Foundation, regular physical exercise can reduce your risk of developing Alzheimer’s disease by up to 50 percent. What’s more, exercise can also slow further deterioration in those who have already started to develop cognitive problems, Gibbs says. The evidence for a beneficial effect of exercise is robust except in the late stage of the disease, when it may be too late to intervene.
Aerobic exercise can also improve the performance of healthy adults on thinking tests. Pulling together the results of 29 clinical trials, a month or more of regular aerobic exercise resulted in improvements in memory, attention and processing speed when compared with regular non-aerobic exercise such as stretching and toning.
2. Eat a plant-based diet
A plant-based, Mediterranean-style diet appears to reduce the risk of getting Alzheimer’s. The evidence is most compelling for a variant of the Mediterranean diet called the MIND diet (Mediterranean intervention for neurodegenerative delay) that emphasises adding green vegetables, berries, nuts and other foods rich in flavanols.
3. Mentally stimulating activity
While games and puzzles may be helpful, it’s particularly important to challenge the brain with new learning, as this is thought to help develop new neuronal pathways and synapses. Examples include reading, learning to play a new musical piece, or studying a new language.
4. Social engagement
This can be hard for people living with Alzheimer’s because apathy is often a part of the disease. There’s evidence that those who remain socially active have slower progression.
The Journal of Alzheimer’s Disease outlined an interesting study on social interaction. This study involved participants without dementia who were involved in a highly interactive discussion group, while others in the study participated in Tai Chi, walking, or were part of the control group who received no interventions. The results showed that those involved in the discussion group not only improved in their cognitive functioning but also increased their brain volumes according to MRIs. A larger brain volume has been correlated with a decreased risk of dementia.
5. Getting adequate sleep
This is an emerging area of research. There appears to be a cleansing of the brain of toxins, including beta-amyloid (a protein which forms sticky plaques in the brains of people with Alzheimer’s) during sleep by the so-called glymphatic circulation. Also, sleep disorders including sleep apnoea are common in patients with Alzheimer’s and should be treated if present.
6. Diabetes and high blood pressure treatment
Both these disorders – diabetes and high blood pressure – can aggravate Alzheimer’s pathology in the brain as well as lead to vascular dementia, a condition that often coexists with Alzheimer’s. Therefore, detecting these issues early and ensuring they’re well managed is also important.
A Tattoo On My Brain will be published by Cambridge UP.