The three men, all aged in their 20s, died at the scene following a collision between the car in which they were travelling and a lorry at around 1.50am on Monday in Garvaghy area.
A fourth man, also in his 20s, is in hospital and is being treated for serious injuries.
It’s understood all of the four men are from the local area.
The Omagh Road was closed for much of the day between the Curr Road and the Greenmount Road.
A PSNI spokesperson said: “Inquires are continuing and anyone who was in the area at the time and may have witnessed the incident or who has dashcam footage or any other information, should contact police on 101 quoting reference number 240 27/12/21.”
Police said the lorry driver was not injured.
SDLP West Tyrone MLA Daniel McCrossan said: “This heartbreaking news is deeply shocking and distressing to us all.
“My thoughts are with the families and friends of these young victims whose lives have been cut short in such tragic circumstances.
“My thoughts are also with the fourth victim who has been taken to hospital for treatment and I would like to wish him a speedy and full recovery.
“I would also appeal to anyone with information about the incident to contact the police.”
Deputy First Minister Michelle O’Neill tweeted: “Heartbreaking news that three young men have lost their lives in a fatal road collision in Garvaghy.
“My thoughts and prayers are with their families, friends and local community.”
West Tyrone MP Orfhlaith Begley said the entire community had been stunned.
She said: “I wish to extend my deepest sympathy to the families of the three young men killed and the young man seriously injured.
“The scale of this tragedy has stunned the entire community, but everyone will rally around to support all those affected in what will be difficult days ahead.
“I wish to pay tribute to the emergency services for all their efforts at the scene.”
Alliance councillor Stephen Donnelly has said the thoughts of the entire community are with the loved ones of three young men who died in the crash.
The trio, in their 20s, died at the scene of the crash involving a car and a lorry on the Omagh Road around 1:50am today (Monday). A fourth man, also in his 20s, has been taken to hospital after sustaining serious injuries.
“The entire community in Tyrone is devastated by this crash and the sad passing of three young men, and the injury to another,” said Stephen.
“I want to express my condolences to the loved ones of those who died, particularly coming at this time of year. I also wish for a swift recovery for the individual injured in this incident. The thoughts of everyone in the local area will be with him as he hopefully recovers quickly.
“The death of someone at Christmas is hard to process, especially in such tragic circumstances. I would urge anyone with information on this to pass it to police immediately.”
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