It is unclear how many vehicles were involved in the crash in Waringstown.
It is understood a power line is also down and across a road.
A PSNI spokesperson said police were attending a road traffic collision in the village.
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“Local diversions are in place, with traffic being diverted via Dunkirk Road and Moss Road.
“Drivers are advised to seek alternative routes for their journeys.”
DUP Cllr Mark Baxter said: “The Lurgan Road, Waringstown is closed on the village side of Dunkirk Road, just at the entrance to Tudor Lodge, due to a road traffic accident and a power line has been hit and across the road. Please avoid.”
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