Drivers are asked to ‘seek alternative routes for your journey’.
Crews from the PSNI and Northern Ireland Fire and Rescue Service are currently at the scene with a cordon in place.
Fire appliances are in place from ‘Central Fire Station and Westland Fire Station, along with an Aerial Appliance and a Specialist Rescue Team’, according to the NIFRS.
They added: “Firefighters were called to reports of a collapsed building this afternoon. The incident is ongoing.”
In a Tweet Police North Belfast said: “ Motorists are advised that the Antrim Road is closed in both directions between the Cavehill Road and Limestone Road due to a collapse of a building wall.
Please seek an alternative route for your journey.”
