McIlroy was part of Ryder Cup-winning squads in 2010, 2012, 2014 and 2018.
He will tee off in Rome aiming to build on a past points record of 2, 3, 3, 3, 2 and 1 towards a run of 12 wins, the same number of defeats and 4 halved.
Joining McIlroy in Luke Donald’s Team Europe squad are Jon Rahm, Viktor Hovland, Tyrrell Hatton, Matt Fitzpatrick, Robert MacIntyre, Tommy Fleetwood, Shane Lowry, Justin Rose, Sepp Straka, Ludvig Aberg and Nicolai Hojgaard.
The 44th edition of the Ryder Cup will run at Marco Simone Golf and Country Club from September 29 to October 01.
1. 2014: Gleneagles
Northern Ireland's Graeme McDowell and Rory McIlroy enjoying Team Europe success. (Photo by Jamie Squire/Getty Images) Photo: Jamie Squire
2. 2016: Hazeltine
Rory McIlroy reacts on the eighth green during singles in Minnesota. (Photo by Sam Greenwood/Getty Images) Photo: Sam Greenwood
3. 2016: Hazeltine
Rory McIlroy at the first tee in Minnesota. (Photo by Streeter Lecka/Getty Images) Photo: Streeter Lecka
4. 2014: Gleneagles
Rory McIlroy with, from left, Sergio Garcia, Lee Westwood and Ian Poulter celebrate winning the Ryder Cup in Scotland. (Photo by Ross Kinnaird/Getty Images) Photo: Ross Kinnaird