Across the weekend, many former Irish League stars or Northern Ireland internationals will take to the pitch in one of the world’s most famous competitions.
Some of the biggest ties see Liverpool hosting Accrington Stanley at Anfield, Chelsea welcoming Morecambe to Stamford Bridge and Tamworth take on Premier League opposition in Tottenham Hotspur.
Here’s every local representative to watch out for over the weekend.
21. Patrick Kelly (Doncaster Rovers)
Former Coleraine midfielder Patrick Kelly has played 17 league games for Doncaster Rovers this season while on-loan from West Ham United and could feature in Sunday's FA Cup clash with Hull City. Photo: Niall Carson/PA Wire
22. Jonny Evans (Manchester United)
Northern Ireland veteran Jonny Evans could be called upon when Manchester United face Arsenal in one of the standout ties on Sunday. Photo: Nick Potts
23. Michael Forbes (Bristol Rovers)
Ex-Dungannon Swifts youngster Michael Forbes joined Bristol Rovers on-loan from West Ham United for this season. He has played seven times in the league but having recently missed a string of matches, it's unclear if he'll return for Sunday's trip to Premier League outfit Ipswich Town. Photo: Bristol Rovers
24. Justin Devenny (Crystal Palace)
Justin Devenny has broken into the Crystal Palace side, scoring a maiden Premier League goal against Aston Villa, and could feature against Stockport County on Sunday. Photo: Nick Potts