Across the weekend, many former Irish League stars or Northern Ireland internationals will take to the pitch in one of the world’s most famous competitions.
Some of the biggest ties see Liverpool hosting Accrington Stanley at Anfield, Chelsea welcoming Morecambe to Stamford Bridge and Tamworth take on Premier League opposition in Tottenham Hotspur.
Here’s every local representative to watch out for over the weekend.
17. Pierce Charles (Sheffield Wednesday)
Pierce Charles impressed when given his chance for Northern Ireland recently and could get a rare Sheffield Wednesday run out during their FA Cup clash away to Coventry City on Saturday afternoon. Photo: Jess Hornby/Getty Images
18. Shea Charles (Sheffield Wednesday)
Northern Ireland international Shea Charles has been linked with a number of clubs, including Celtic, but should be involved for Sheffield Wednesday in their FA Cup clash with Coventry City. Photo: Liam McBurney/PA Wire
19. Ethan Galbraith (Leyton Orient)
Former Linfield and Manchester United youngster Ethan Galbraith has been a consistent performer for Leyton Orient and will hope to feature when his side face Derby County on Saturday. Photo: Steven Paston
20. Jamie Donley (Leyton Orient)
Born in Antrim, Tottenham youngster Jamie Donley's international future remains up in the air after representing both Northern Ireland and England at youth level. He has scored four league goals while on loan at Leyton Orient. Photo: Jonathan Porter/PressEye