The collision happened on the Trewmount Road between Dungannon and Moyin Co Tyrone.
A post on PSNI Facebook last night said: "Sadly a man has died following the collision earlier on the Trewmount Road in Moy.
"A number of others who were injured are still receiving treatment."
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This morning post from TrafficwatchNI said: "The Trewmount Road between #Dungannon and #Moy remains closed this morning after a serious RTC last night.
"Likely to be closed all morning. Seek an alternative route."